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Table 2 Anchored susceptibility modules

From: Integrated genomics of susceptibility to alkylator-induced leukemia in mice

   

BXD

    

Module

Anchor Gene

KL

KLS

KLS-

Gr

Ter

N*

P-value#

Top GO

Top KEGG

A_1

LOC634046

460

43

2

23

199

236

2.25

GO:0032940

NE

A_2

scl41743.2_361

402

140

272

207

19

329

1.09

GO:0019219

map04120

A_3

GI_38089999

38

4

1

0

2

7

1.72

NE

NE

A_4

A330106M24Rik

4

3

3

3

1

4

1.82

NE

NE

A_6

Ociad2

132

63

3

16

10

75

1.5

GO:0043666

NE

A_7

GI_46852192-I

97

1

15

1

50

54

1.95

GO:0051329

NE

A_9

Zfp862

106

13

19

1

0

26

2.3

NE

NE

A_12

A630001G21Rik

112

79

50

38

48

104

2.38

GO:0045449

NE

A_14

Aste1

102

7

48

0

1

52

2.67

NE

NE

A_16

Ckap2l

607

4

116

289

4

356

1.28

GO:0006281

map04070

A_17

H2-Ke6

238

12

109

2

81

152

1.93

NE

NE

A_20

Dusp16

91

45

4

43

30

72

2.08

NE

NE

A_21

scl0217069.13_16

58

3

4

21

4

29

2.72

NE

NE

A_22

Atf7ip

39

1

1

9

10

19

2.61

NE

NE

A_23

Snrpn

4

2

2

0

1

3

0.94

NE

NE

A_24

Atp6v0e2

78

4

5

1

0

5

2.91

NE

NE

A_25

Gimap7

30

3

2

0

6

9

2.35

NE

NE

A_26

Pdzk1ip1

79

39

31

0

20

57

2.35

NE

NE

A_27

Polr1b

27

3

10

4

2

12

3.11

NE

NE

A_28

Magohb

65

55

35

24

47

61

0.97

GO:0044242

NE

A_30

Sox13

34

18

25

3

1

29

1.45

GO:0006631

NE

A_32

Ptcd3

18

7

14

5

4

17

2.68

NE

NE

A_33

Casp9

37

1

0

6

1

6

3.22

NE

NE

A_34

Ctsf

223

53

123

8

71

169

2.34

NE

NE

A_36

scl46617.10.1_4

13

4

3

8

5

10

2.5

NE

NE

A_37

Parp2

88

21

21

17

19

42

2.05

NE

NE

A_38

Hdhd3

178

72

2

70

1

102

1.78

NE

NE

A_39

5830417I10Rik

5

1

3

1

1

3

2.07

NE

NE

A_41

Prcp

3

2

1

2

2

3

2.11

NE

NE

A_43

Ggcx

7

6

7

5

3

7

2.53

NE

NE

  1. KL: Number of probes significantly associated with anchored gene expression in kit+/lineage- (KL) cells.
  2. BXD: Number of probes in module significantly associated with anchored gene expression in BXD KLS (Sca+/kit+/lineage-, HSC), KLS- (Sca-/kit+/lineage-, Progenitor), Gr-1+ (Myeloid), or Ter-119+ (Erythroid) cells.
  3. *, Number of probes in module significantly associated with anchored gene expression in at least one BXD data set.
  4. #, -Log10(P-value) for association with t-AML susceptibility.
  5. Top GO/KEGG, annotations significantly enriched in each module; NE, not enriched.
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BMC Genomics

ISSN: 1471-2164

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