Figure 1From: LAB-Secretome: a genome-scale comparative analysis of the predicted extracellular and surface-associated proteins of Lactic Acid BacteriaThe flowchart for constructing the secretome LaCOGs. The completely sequenced LAB genomes are used as input data. No plasmid sequences were used for the Inparanoid search. The squares with dash-line frames are intermediate products that are not user-queryable from the LAB-Secretome interface; the squares with full-line frames are the final information stored in LAB-Secretome database. The upper left frame shows the processes that produce new LACOGs; the upper right frame shows the processes that extend existing LaCOGs. The new LaCOGs are coded starting with "9", the extended existing LaCOGs retain the original names from Makarova et.al [43]. BlastP1: the Blast results were processed by a revised criterion "uniform top 3" (see Material and Methods); BlastP2: the Blast results were processed by cut-off of 1e-3 and aligned sequence coverage of 60% for distant homolog identification. This work scheme can be used to update the LAB-Secretome database when new bacterial genomes are available.Back to article page