The kinome of Phytophthora infestans reveals oomycete-specific innovations and links to other taxonomic groups

BMC Genomics

Table 2 Non-kinase domains in ePKs from P. infestans

Pfam Domain	No. of Proteins^a	Represented Families	Function	Novel?^b
Ankyrin	3	AGC, TKL	higher order structure
Arb2	2	AGC	chromatin association	✓
Armadillo	1	TKL	protein interaction
C2	1	AGC	Ca²⁺-dependent membrane targeting
cNMP binding	8	AGC, CAMK	cyclic nucleotide binding
cyclin N, C	4	CMGC	cell cycle control	✓
DEP	5	AGC, TKL	protein targeting and interaction
EF hand	3	CAMK, OTHER	calcium binding
FYVE	2	AGC	zinc binding
HEAT	1	OTHER	protein interaction
KA1	4	CAMK	kinase associated, unknown
LRR	16	TKL	protein interaction
NAF	2	CAMK	unknown
PAS	1	CMGC	signal sensor	✓
PDZ	1	TKL	protein interaction
PH	9	AGC, CAMK, CMGC	phosphatidylinositol binding
PhoD	1	STE	phosphatase
PP2C	4	AGC, CAMK, OTHER	protein phosphatase
PX	3	AGC	phosphoinositide binding
Response Reg	1	OTHER	two-component signaling
RhoGAP	1	STE	GTPase activating protein	✓
RWD	2	OTHER	unknown
RyR	1	CAMK	unknown	✓
SAM	2	STE, TKL	protein interaction
SET	1	CMGC	protein interaction
TPR	1	TKL	protein interaction
UBA/TS-N	1	CAMK	ubiquitin binding
WD40	1	OTHER	protein interaction
WW	1	CMGC	protein interaction	✓
ZF-B	1	STE	zinc binding

^a If a protein contains more than one given domain it is counted only once in that category.
^b Indicates combination of kinase domain and accessory domain not reported previously outside of Phytophthora.

ISSN: 1471-2164