Figure 4

Survival analysis for the TNFAIP1/POLDIP2 gene pair in breast cancer patients. A, B and C -- plots and histogram for the Stockholm cohort; D, E and F - plots and histogram for the Uppsala cohort. Black indicates the low-risk prognosis group, red indicates the high risk prognosis group. A and D - correlation of gene expression and optimal partition of expression domains and patients grouping. The horizontal lines are the cut-offs of 2D data-driven grouping. B and E - Kaplan-Meier survival curves for TNFAIP1 and POLDIP2 when analyzed separately (TNFAIP1 - dotted line; POLDIP2 -- dashed line) as well as together (solid line). C and F -- separation of breast cancer patients based on expression data of the TNFAIP1/POLDIP2 gene pair in different grades [15]: Y axis -- frequency of patients in different groups; X axis -- patient distribution in different breast cancer grades (white column - total group; black column -- low-risk prognosis group; red column -- high risk prognosis group).