Feature amplified voting algorithm for functional analysis of protein superfamily

BMC Genomics

Table 1 Functional annotations of the residues in rat imidase selected by FAVAT

FAVAT score ranking	FAVAT selected residues	Corresponding residues in 1GKQ¹	Corresponding residues in 1KCX¹	MSA predicted residues²	Functional annotation base on 1GKQ
1	His248	His239	Lys254	His239	Metal coordinate
2	His69	His61	Tyr75	His61	Metal coordinate
3	Arg302	Arg292	Ser308		Conformation
4	Lys159	Lys150 (Kcx)	Gln165		Metal coordinate
5	Met297	Met287	Thr303		Conformation
6	His67	His59	Asn73	His59	Metal coordinate
7	Asp326	Asp315	Gly332		Metal coordinate
8	Ala134	Ala126	Asp139		Secondary structure core residue
9	Ala34	Arg30	Gln44		Quaternary structure
10	His459	Trp448	Met465		Quaternary structure

¹GKQ and 1KCX are the structure IDs of D-hydantoinase and collapsin response mediator proteins (CRMPs), respectively.
²MSA result according to the manuscript [66].

ISSN: 1471-2164