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Table 4 List of the human genes in the INHGI with the 10 highest morbidity scores

From: A machine learning approach for genome-wide prediction of morbid and druggable human genes based on systems-level data

Gene

  

Morbidity score

  

(Median [min,max])1

  

N

  

W

W c 2 (two-tailed p = 0.05)

Morbidity evidence3

   

Normal

  

Shuffled

    

TFRC

  

0.880 [0.576,0.939]

  

0.568 [0.447,0.678]

  

10

  

1

8*

5941956

ITGA5

  

0.875 [0.635,0.916]

  

0.491 [0.377,0.631]

  

10

  

0

8*

No evidence

LTF

  

0.868 [0.803,0.913]

  

0.509 [0.356,0.642]

  

10

  

0

8*

19258923

SFTPD

  

0.866 [0.618,0.923]

  

0.565 [0.458,0.682]

  

10

  

2

8*

19590686

THBS1

  

0.865 [0.831,0.918]

  

0.511 [0.354,0.566]

  

10

  

0

8*

18178577

TIMP2

  

0.860 [0.603,0.92]

  

0.574 [0.388,0.609]

  

10

  

0

8*

19933216

TGFB2

  

0.857 [0.565,0.918]

  

0.526 [0.407,0.707]

  

10

  

3

8*

19258923

CGA

  

0.856 [0.62,0.916]

  

0.535 [0.283,0.656]

  

10

  

0

8*

19730683

SPP1

  

0.856 [0.577,0.887]

  

0.564 [0.34,0.696]

  

10

  

0

8*

15868370

FLT1

  

0.854 [0.61,0.931]

  

0.527 [0.424,0.715]

  

10

  

3

8*

19741061

NOL3

  

0.850 [0.647,0.875]

  

0.576 [0.31,0.651]

  

10

  

1

8*

19773279

  1. 1 Of 10 scores
  2. 2 According to table of critical values for W in [6]
  3. 3 Pudmed IDs of most recent article(s) clearly stating a gene-disease association
  4. * Difference statistically significant
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BMC Genomics

ISSN: 1471-2164

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