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Table 1 Gene Ontology (GO) categories over-represented in groups of responsive and non-responsive genes

From: Responsiveness of genes to manipulation of transcription factors in ES cells is associated with histone modifications and tissue specificity

Group of genes

GO id

GO name

N genes

p-value

Enrichment ratio

Responsive genes with CpG islands

GO:0048513

Organ development

543

0

2.233

 

GO:0003700

Transcription factor

323

0

2.198

 

GO:0007399

Nervous system devel.

268

0

2.351

 

GO:0007155

Cell adhesion

211

0

2.032

 

GO:0006928

Cell motility

134

6.6027E-12

2.095

 

GO:0009888

Tissue development

125

1.0458E-13

2.322

 

GO:0031012

Extracellular matrix

115

3.245E-11

2.175

 

GO:0001568

Blood vessel devel.

107

0

3.313

 

GO:0007507

Heart development

85

2.8866E-15

3.122

 

GO:0016055

Wnt receptor signaling

60

1.1637E-10

3.008

Non-responsive genes with CpG islands

GO:0015031

Protein transport

370

0

2.147

 

GO:0006396

RNA processing

236

0

3.403

 

GO:0006412

Translation

228

0

3.154

 

GO:0044429

Mitochondrial part

206

4.4409E-16

2.475

 

GO:0022403

Cell cycle phase

161

4.5759E-10

2.141

 

GO:0016887

ATPase activity

158

1.3717E-10

2.278

 

GO:0008380

RNA splicing

133

0

5.358

 

GO:0006281

DNA repair

124

1.6187E-13

3.088

 

GO:0006260

DNA replication

92

1.5896E-09

2.864

 

GO:0006457

Protein folding

78

6.4245E-07

2.484