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Figure 4 | BMC Genomics

Figure 4

From: Meta-analysis of heterogeneous Down Syndrome data reveals consistent genome-wide dosage effects related to neurological processes

Figure 4

Novel DS dosage effects visualised with the web browser. A) SST and TAC1 have been previously reported as acting in a complex. The deregulated profile of these genes correlates was shown here with the fold-change view of the web browser. B) HSPA5 is a novel gene for DS implicated in neurodegeneration which is also a target of the ATF6 TF whose target set was enriched with significant genes. The histogram displays the p-values for this gene in individual studies. C) KANK1, a gene previously related with paternally inherited cerebral palsy, shows a consistent trend of up-regulation in the considered studies as shown with the fold-change view of the web browser.

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BMC Genomics

ISSN: 1471-2164

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