Table 4 Polar metabolites significantly affected by TCDD exposure.
Metabolite | Change fold (1H NMR p < 0.01) | Change fold (LC-MS p < 0.01) |
|---|---|---|
Leucine, Isoleucine | 0.69 | 0.64 |
Valine | 0.72 | 0.69 |
Alanine | 0.68 | -- |
N-acetyl-aspartate | 0.68 | 0.72 |
Glutamate | 0.79 | 0.80 |
Glutamine | 0.69 | -- |
Glycine | 0.72 | -- |
Aspartate | 0.66 | -- |
Serine | 0.65 | -- |
Tyrosine | 0.58 | 0.44 |
Proline | -- | 0.54 |
Tryptophan | -- | 0.79 |
Lactate | 0.49 | -- |
Spermidine | -- | 0.24 |
N1-acetyl-spermidine | -- | 0.59 |
Pantothenic acid | -- | 0.62 |
Creatine/Phosphocreatine | 0.66 | -- |
Propyonylcarnitineb | -- | 0.66 |
Butyrylcarnitine | -- | 0.58 |
Nucleotides (AXP and UMP) | 0.3-0.6 | -- |
UMP | -- | 0.71 |
AMP | -- | 0.67 |
Oxidized glutathione | 1.26 | 1.31 |
Reduced glutathione | 1.58 | 1.23 |
Taurine | 1.37 | -- |
Citrate | 1.46 | 1.68 |
UDP-N-acetyl-galactosamine/glucosamine* | -- | 1.48 |