Table 2 Gene description (according to SAPD database [28]), GO classification, FC and scores of common genes regulated during mineralization of VSa13 cells (FCM) versus mineralization with vanadate (FCMV)
Gene description | GOBP/MF | FCM | FCMV | Score |
|---|---|---|---|---|
Photoreceptor outer segment all-trans retinol dehydrogenase [Source:IPIAcc:IPI00024598] | metabolic process/oxidoreductase activity | 34,8 | 0,14 | 240,1 |
AMBP protein precursor [Source:Uniprot/SWISSPROTAcc:P02760] | -/- | 47,4 | 0,36 | 131,5 |
Ependymin related protein-1 precursor [Source:IPIAcc:IPI00554718] | cell-matrix adhesion/calcium ion binding | 15,2 | 0,14 | 111,8 |
Xaa-Pro aminopeptidase 2 precursor [Source:Uniprot/SWISSPROTAcc:O43895] | proteolysis, creatine metabolic process/metalloexopeptidase activity, hydrolase activity, creatinase activity | 27,2 | 0,25 | 110,2 |
No match | -/- | 28,2 | 0,31 | 89,73 |
Microtubule-associated proteins 1A/1B light chain 3C precursor [Source:Uniprot/SWISSPROTAcc:Q9BXW4] | -/- | 12,6 | 0,14 | 89,63 |
Cell death activator CIDE-3 [Source:Uniprot/SWISSPROTAcc:Q96AQ7] | apoptosis/protein binding | 7,77 | 0,17 | 45,71 |
No match | -/- | 25,5 | 0,61 | 41,50 |
No match | -/- | 12,7 | 0,32 | 39,97 |
PREDICTED: hypothetical protein [Danio rerio] | pore complex biogenesis/channel activity | 18,3 | 0,52 | 35,20 |
Hypothetical protein LOC447879 [Source:RefSeq_peptideAcc:NP_001004618] | integrin-mediated signaling pathway/- | 9,55 | 0,29 | 32,64 |
No match | -/- | 17,5 | 0,54 | 32,31 |
Granulocyte-macrophage colony-stimulating factor receptor alpha chain precursor [Source:Uniprot/SWISSPROTAcc:P15509] | -/- | 8,69 | 0,29 | 29,83 |
No match | -/- | 5,77 | 0,21 | 27,18 |
IgGFc-binding protein precursor [Source:Uniprot/SWISSPROTAcc:Q9Y6R7] | cell adhesion/- | 4,35 | 0,19 | 23,12 |
No match | -/- | 6,28 | 0,28 | 22,13 |
Hydroxyacid oxidase 2 [Source:Uniprot/SWISSPROTAcc:Q9NYQ3] | metabolic process, electron transport/oxidoreductase activity | 5,21 | 0,24 | 21,38 |
No match | -/- | 7,70 | 0,39 | 19,85 |
No match | -/- | 7,35 | 0,37 | 19,79 |
Phosphatase and actin regulator 4 isoform 1 [Source:RefSeq_peptideAcc:NP_001041648] | -/- | 4,95 | 0,27 | 18,08 |
Ependymin related protein-1 precursor [Source:IPIAcc:IPI00554718] | cell-matrix adhesion/calcium ion binding | 2,54 | 0,14 | 18,02 |
No match | -/- | 8,95 | 0,52 | 17,26 |
No match | -/- | 10,6 | 0,62 | 17,00 |
No match | -/- | 6,53 | 0,39 | 16,57 |
Glucose-6-phosphate 1-dehydrogenase [Source:Uniprot/SWISSPROTAcc:P11413] | glucose metabolic process/glucose-6-phosphate dehydrogenase activity | 4,30 | 0,27 | 16,05 |
Glutamate--cysteine ligase catalytic subunit [Source:Uniprot/SWISSPROTAcc:P48506] | -/- | 4,71 | 0,29 | 16,04 |
Complement factor I precursor [Source:Uniprot/SWISSPROTAcc:P05156] | proteolysis/catalytic activity, serine-type endopeptidase activity, hydrolase activity, scavenger receptor activity | 2,58 | 0,16 | 15,91 |
No match | -/- | 5,66 | 0,41 | 13,71 |
No match | -/- | 4,30 | 0,33 | 12,95 |
No match | -/- | 3,64 | 0,29 | 12,77 |
No match | -/- | 4,93 | 0,39 | 12,73 |
No match | -/- | 5,41 | 0,43 | 12,69 |
Hypothetical protein LOC406276 [Source:RefSeq_peptideAcc:NP_998168] | -/calcium ion binding | 5,07 | 0,40 | 12,54 |
Hypothetical protein LOC336637 [Source:RefSeq_peptideAcc:NP_956317] | cell redox homeostasis/- | 4,66 | 0,38 | 12,17 |
Actin filament-associated protein 1-like 2. [Source:Uniprot/SWISSPROTAcc:Q8N4X5] | -/- | 5,69 | 0,48 | 11,79 |
Transcribed locus, weakly similar to NP_175293.1 [Source:UniGeneAcc:Tru.931] | metabolic process/methyltransferase activity | 2,82 | 0,24 | 11,69 |
No match | -/- | 5,96 | 0,51 | 11,66 |
Ornithine carbamoyltransferase, mitochondrial precursor [Source:Uniprot/SWISSPROTAcc:P00480] | -/ornithine carbamoyltransferase activity, amino acid binding | 4,17 | 0,37 | 11,38 |
No match | -/- | 4,83 | 0,42 | 11,38 |
CDNA FLJ31025 fis, clone HLUNG2000501. [Source:Uniprot/SPTREMBLAcc:Q96ND9] | -/- | 3,80 | 0,34 | 11,25 |
No match | -/- | 3,71 | 0,34 | 11,05 |
No match | -/- | 4,39 | 0,40 | 10,89 |
No match | -/- | 4,76 | 0,45 | 10,59 |
Stromal cell-derived factor 1 precursor [Source:Uniprot/SWISSPROTAcc:P48061] | -/- | 3,94 | 0,38 | 10,36 |
ADM precursor [Source:Uniprot/SWISSPROTAcc:P35318] | -/- | 3,68 | 0,36 | 10,10 |
Beta-2-glycoprotein 1 precursor [Source:Uniprot/SWISSPROTAcc:P02749] | -/- | 4,44 | 0,44 | 10,05 |
No match | -/- | 3,37 | 0,34 | 10,03 |
No match | -/- | 0,05 | 5,03 | 102,8 |
Signal peptide, CUB and EGF-like domain-containing protein 2 precursor [Source:Uniprot/SWISSPROTAcc:Q9NQ36] | -/calcium ion binding | 0,09 | 7,02 | 78,01 |
No match | -/- | 0,18 | 10,7 | 58,98 |
Actin, alpha skeletal muscle 1. [Source:Uniprot/SWISSPROTAcc:P68140] | -/structural molecule activity, ATP binding, protein binding | 0,44 | 17,1 | 38,39 |
No match | -/- | 0,05 | 1,77 | 36,79 |
No match | -/- | 0,09 | 3,03 | 34,37 |
No match | -/- | 0,45 | 14,9 | 33,47 |
Inter-alpha globulIn InhIbItor H3 [Source:IPIAcc:IPI00028413] | hyaluronan metabolic process/serine-type endopeptidase inhibitor activity | 0,18 | 4,41 | 24,67 |
No match | -/- | 0,09 | 1,92 | 21,62 |
Hypothetical protein LOC553753 [Source:RefSeq_peptideAcc:NP_001018560] | -/protein binding | 0,13 | 2,84 | 21,14 |
No match | -/- | 0,15 | 3,18 | 20,60 |
Tenascin precursor [Source:Uniprot/SWISSPROTAcc:P24821] | signal transduction/receptor binding | 0,19 | 3,87 | 20,56 |
No match | -/- | 0,14 | 2,77 | 20,33 |
Prolargin precursor [Source:Uniprot/SWISSPROTAcc:P51888] | -/- | 0,16 | 3,06 | 18,89 |
Eukaryotic translation initiation factor 4E-1A-binding protein [Source:Uniprot/SWISSPROTAcc:Q98TT6] | negative regulation of translational initiation/eukaryotic initiation factor 4E binding | 0,24 | 2,84 | 12,02 |
No match | -/- | 0,40 | 4,76 | 11,87 |
No match | -/- | 0,18 | 2,01 | 11,27 |
WNT1-inducible-signaling pathway protein 1 precursor [Source:Uniprot/SWISSPROTAcc:O95388] | regulation of cell growth/insulin-like growth factor binding | 0,26 | 2,78 | 10,77 |
No match | -/ | 0,29 | 3,00 | 10,34 |