Table 3 Gene description (according to SAPD database [28]), GO classification and FC common genes regulated during mineralization of VSa13 cells (FCM) versus mineralization + vanadate (FCMV) versus proliferation + vanadate
Gene description | GOBP/MF | FCM | FCMV | FCPV |
|---|---|---|---|---|
Ependymin related protein-1 precursor [Source:IPIAcc:IPI00554718] | cell-matrix adhesion/Ca ion binding | 15.21 | 0.14 | 0.59 |
No match | -/- | 5.77 | 0.21 | 0.28 |
Xaa-Pro aminopeptidase 2 precursor [Source:Uniprot/SWISSPROTAcc:O43895] | creatine metabolic process, proteolysis/metalloexopeptidase activity, hydrolase activity, creatinase activity | 27.2 | 0.25 | 0.35 |
No match | -/- | 2.13 | 0.30 | 0.24 |
No match | -/- | 3.37 | 0.34 | 0.54 |
Beta-2-glycoprotein 1 precursor [Source:Uniprot/SWISSPROTAcc:P02749] | -/- | 4.44 | 0.44 | 0.25 |
Translation initiation factor eIF-2B subunit [Source:Uniprot/SWISSPROTAcc:Q9UI10] | -/- | 1.96 | 0.49 | 0.58 |
Rap1b. [Source:Uniprot/SPTREMBLAcc:Q9YH37] | small GTPase mediated signal transduction/GTP binding | 2.08 | 0.51 | 0.51 |
Ribonucleoside-diphosphate reductase large subunit [Source:Uniprot/SWISSPROTAcc:P23921] | DNA replication/ribonucleoside-diphosphate reductase activity, protein binding | 2.19 | 0.51 | 0.66 |
C9orf119 [Source:Uniprot/SPTREMBLAcc:Q8N2W6] | -/- | 2.65 | 0.53 | 0.59 |
No match | -/- | 4.00 | 0.53 | 0.43 |
Protein arginine N-methyltransferase 1 [Source:Uniprot/SWISSPROTAcc:Q99873] | -/- | 3.90 | 0.54 | 0.62 |
ADP-ribosylation factor 5 [Source:RefSeq_peptideAcc:NP_001653] | small GTPase mediated signal transduction/GTP binding | 3.35 | 0.55 | 0.61 |
Argininosuccinate synthase [Source:Uniprot/SWISSPROTAcc:P00966] | arginine biosynthetic process/argininosuccinate synthase activity, ATP binding | 3.76 | 0.55 | 0.60 |
Serine/threonine-protein kinase 19. [Source:Uniprot/SWISSPROTAcc:P49842] | -/- | 2.25 | 0.57 | 0.54 |
No match | -/- | 3.82 | 0.59 | 0.53 |
Phosphate-regulating neutral endopeptidase [Source:Uniprot/SWISSPROTAcc:P78562] | proteolysis/neprilysin activity; metallopeptidase activity, hydrolase activity, Zn ion binding | 5.42 | 0.61 | 0.39 |
No match | -/- | 2.33 | 0.61 | 0.44 |
Kinetochore-associated protein [Source:Uniprot/SWISSPROTAcc:Q96IY1] | -/ | 3.20 | 0.63 | 0.56 |
glyoxalase domain containing 5 [Source:RefSeq_peptideAcc:NP_001073958] | -/- | 3.81 | 0.64 | 0.58 |
BolA-like protein 2. [Source:Uniprot/SWISSPROTAcc:Q9H3K6] | -/- | 1.53 | 0.66 | 0.59 |
Cyclin-dependent kinases regulatory subunit 1 [Source:IPIAcc:IPI00015104] | cell cycle/cyclin-dependent protein kinase regulator activity, kinase activity | 3.45 | 0.66 | 0.52 |
Signal peptide, CUB and EGF-like domain-containing protein 2 precursor [Source:Uniprot/SWISSPROTAcc:Q9NQ36] | -/Ca ion binding | 0.09 | 7.02 | 5.19 |
No match | -/- | 0.05 | 5.03 | 2.48 |
Inter-alpha globulIn InhIbItor H3 [Source:IPIAcc:IPI00028413] | hyaluronan metabolic process/serine-type endopeptidase inhibitor activity | 0.18 | 4.38 | 2.71 |
Tenascin precursor [Source:Uniprot/SWISSPROTAcc:P24821] | signal transduction/receptor binding | 0.19 | 3.87 | 1.55 |
Prolargin precursor [Source:Uniprot/SWISSPROTAcc:P51888] | -/- | 0.16 | 3.06 | 2.05 |
No match | -/- | 0.29 | 3.00 | 1.82 |
No match | -/- | 0.54 | 2.76 | 2.82 |
No match | -/- | 0.29 | 2.69 | 2.87 |
No match | -/- | 0.29 | 2.62 | 1.75 |
Thrombospondin 1 precursor [Source:RefSeq_peptideAcc:NP_003237] | cell adhesion/structural molecule activity, Ca ion binding | 0.29 | 2.53 | 2.28 |
No match | -/- | 0.34 | 2.14 | 1.74 |
No match | -/- | 0.51 | 1.81 | 2.02 |