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Figure 3 | BMC Genomics

Figure 3

From: MicroRNA genes preferentially expressed in dendritic cells contain sites for conserved transcription factor binding motifs in their promoters

Figure 3

TFBSs shared among the promoter regions of miRNAs up-regulated in DCs. (A) Shown on the x-axis are the high-scoring TFBSs (i.e. of instance score ≥ 6) that occur at least once in the 2 kb promoters of the miRNA up-regulated in DCs. The y-axis shows the number of promoters that have the TFBS at least once at this threshold. (B) The distribution of the number of common TFBS hits per number of common miRNA promoters as in A, for DCs and random sets of miRNA promoters. The values for random are the median values from 1000 randomly chosen sets of 12 miRNA promoters. The score is the ratio of the sum of all TFBS occurrences across all promoters for the DC set relative to that of the random set. The p-value is the fraction of cases wherein this sum for random sets of miRNA promoters is greater than or equal to that of the DC set.

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BMC Genomics

ISSN: 1471-2164

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