Table 2 A summary of gene expression changes induced by BaP in MCF7 cells using microarray and RT-PCR analysis

CYP1A1

Xenobiotic metabolism

↑ 91.5-fold

─

↑ 1866.8-fold

─

↑ 73.7-fold

─

CYP1B1

Xenobiotic metabolism

↑ 19-fold

↑ 2.7-fold

↑ 40.4-fold

↑ 3.2-fold

↑ 21.9-fold

↑ 2.3-fold

GDF15

Cell differentiation

↑ 11.2-fold

─

↑ 22.5-fold

↑ 8.9-fold

↑ 2-fold

─

TIPARP

PARP family

↑ 5.5-fold

─

↑ 5.8-fold

↑ 2.9-fold

↑ 6-fold

↑ 4.7-fold

JUN

Cell proliferation

↑ 5.5-fold

↑ 1.8-fold

↑ 5.1-fold

↑ 3.6-fold

─

─

p21

cell cycle checkpoints

↑ 3.2-fold

─

↑ 6.6-fold

─

─

─

RASAL1

Ras regulator

↑ 3.4-fold

─

↑ 2.8-fold

↑ 3.3-fold

─

↓ 2.8-fold

RGC32

Cell cycle control

↑ 2.9-fold

↑ 1.6-fold

↑ 2.3-fold

─

↑ 2.3-fold

↑ 1.5-fold

ALDH1A3

Xenobiotic metabolism

↑ 1.7-fold

─

↑ 4.2-fold

↑ 4.3-fold

↑ 2.4-fold

─

DLX2

Development

↑ 1.5-fold

─

↑ 4.8-fold

↑ 5-fold

↑ 2.5-fold

↑ 3.3-fold

CEBPA

Mitotic growth arrest

↑ 1.7-fold

─

─

─

↑ 1.5-fold

↑ 1.7-fold

NRF2

Oxidative stress

↑ 1.5-fold

─

─

─

↑ 1.6-fold

↑ 1.6-fold

ATF3

Transcription Factor

↑ 3-fold

─

↑ 6.1-fold

↑ 4.5-fold

─

DNAJB4

Oxidative stress

↑ 2.2-fold

─

↑ 1.6-fold

↑ 1.9-fold

─

↑ 1.5-fold

Bax

Apoptosis

↑ 1.5-fold

─

↑ 1.6-fold

─

─

↑ 1.6-fold

SPRY4

MAPK signalling

─

─

─

↑ 4.5-fold

↑ 1.7-fold

─

GSTT2

Xenobiotic metabolism

↑ 2.8-fold

↑ 1.7-fold

─

─

─

─

CABLES2

Apoptosis

─

─

─

─

─

↑ 2.3-fold

PTGER4

T-cell factor signalling

─

↑ 2.7-fold

↑ 1.5-fold

─

─

↑ 2.2-fold

BBC3

Apoptosis

─

─

↑ 2.1-fold

↑ 5-fold

─

↑ 1.9-fold

EGR1

Cell growth and proliferation

↑ 6.7-fold

↑ 2.7-fold

↑ 2.5-fold

─

─

─

CTNNB1

Cell adhesion

↑ 1.5-fold

↑ 2.25-fold

─

─

─

─

PLK3

Cell cycle control

─

─

↑ 2.5-fold

↑ 3.4-fold

─

─

AFF4

Transcription Elongation

─

─

─

↓ 2.6-fold

↓ 1.5-fold

↓ 6.2-fold

ZBRK1

DNA damage response

─

─

─

↓ 4.7-fold

─

─

DKK1

Wnt/Catenin

↓ 7-fold

↓ 3.1-fold

↓ 2.8-fold

─

↓ 2.4-fold

─

KAT2B

Transcription regulation

↓ 4.6-fold

─

↓ 3-fold

─

↓ 6.5-fold

↓ 1.7-fold

RASGRP1

Ras signalling

↓ 3.8-fold

↓ 1.5-fold

↓ 2.2-fold

─

↓ 6-fold

↓ 2-fold

JMJD2C

Histone demethylase

↓ 3.6-fold

─

↓ 4.5-fold

↓ 2-fold

↓ 3-fold

↓ 1.8-fold

HDAC4

Cell cycle control

↓ 2.1-fold

─

↓ 2.7-fold

↓ 1.8-fold

↓ 1.8-fold

─

FERMT1

Actin cytoskeleton

↓ 2.1-fold

↓ 6.7-fold

↓ 1.8-fold

─

↓ 2.5-fold

─

Scaper

cell cycle checkpoints

↓ 1.8-fold

↓ 1.5-fold

↓ 1.8-fold

↓ 2-fold

↓ 2.8-fold

↓ 2.2-fold

NPM1

Cell proliferation/Apoptosis

─

─

─

─

─

↑ 2.4-fold

YWHAQ

Cell cycle control/Apoptosis

─

─

─

─

─

─

AHR

Xenobiotic Metabolism

─

─

─

─

─

─

p53

Tumour Suppressor

─

─

─

─

─

─

RFC5

Replication Factor

─

↑ 1.8-fold

─

─

─

─

Hint1

Apoptosis

─

↑ 2.2-fold

─

─

─

↑ 1.5-fold

NQO1

Xenobiotic metabolism

─

↑ 2.2-fold

─

─

─

─