Figure 3

A small part of the differential disease regulome, showing a cluster of TFs associated with a range of lipid metabolism disorders in addition to gallstone, including dendrograms of the hierarchical clustering of the TFs and diseases. The disease category "Diseases in Twins" seems to have joined the cluster because of twin studies on lipid metabolism and gallstone. The color of each square indicates the difference between the observed and expected number of gene regions with TF bindings, as denoted by z-scores calculated under the specific null hypothesis. Black denotes no difference, blue to cyan (lowest) denotes under-representation, while red to yellow (highest) represent over-representation of TF binding. Small circles denote significant under-or over-representation, as calculated by the appropriate hypothesis test (see Additional file 1). Different parts of the regulome have been joined together in the figure and dendrograms have been shortened for illustrative purposes.