Figure 1From: An RNA interference screen for identifying downstream effectors of the p53 and pRB tumour suppressor pathways involved in senescenceCharacteristics of CL3EcoR cells. a: CL3EcoR cells are immortal at 34°C but undergo a senescence arrest upon shift up 38°C. b: Senescence is bypassed upon silencing of p21CIP1 using pRSp21F or sequestration of RB family of proteins by HPV16 E7.Back to article page