A codon substitution model that incorporates the effect of the GC contents, the gene density and the density of CpG islands of human chromosomes

Table 2 Correlation coefficient analysis between ln (substitution rate ×10⁸) and chromosomal features

Type	Grantham Distance	GC Content (%)	Gene Density^a	CpG Island Density^a	Chromosome Size
CpG to TpG	-0.23**	-0.04**	-0.03**	-0.08**	-0.13**
TpG to CpG	-0.39**	0.09**	0.09**	0.02*	-0.25**
non-CpG Transition	-0.35**	0.08**	0.08**	0.01**	-0.24**
Transversion	-0.23**	0.06	0.07**	-0.02**	-0.32**

ISSN: 1471-2164