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Table 1 Cell cycle and cell growth genes responsive to MYC-ERTAM activation

From: Deciphering c-MYC-regulated genes in two distinct tissues

  

Pancreatic β-Cells

Suprabasal Keratinocytes

 

Gene Symbol

RefSeq

4 Hours

8 Hours

16 Hours

32 Hours

4 Hours

8 Hours

16 Hours

32 Hours

Myc-response p-value

Cell Cycle

          

ccna2

X75483

0.96

4.52**

10.49**

3.25**

0.81

0.67

1.39

0.97

2.05E-02

ccna2

X75483

0.55**

1.33*

12.39**

3.47**

0.63**

0.71*

0.99

1.05

1.12E-02

ccnb1

NM_007629

1.02

0.90

2.38**

1.13

0.48**

1.03

1.01

0.58**

9.74E-03

ccnb1

NM_007629

1.06

2.85**

8.15**

3.62**

0.60

0.46*

1.39

0.61

3.73E-02

ccnd1

NM_007631

1.86**

2.09**

0.88

1.45

1.13

1.31

1.79*

1.04

4.55E-02

ccnd1

NM_007631

1.69

2.38

1.41

2.27*

1.05

1.33

1.72

1.26

2.24E-02

ccnd1

NM_007631

3.41**

2.74*

2.03*

2.05

1.35

0.99

1.54

1.81

2.23E-02

ccnd2

NM_009829

1.63*

0.61*

2.28**

2.95**

1.37

1.46

0.94

1.40

2.62E-02

ccnd2

NM_009829

1.82

1.03

1.22

1.90*

0.83

1.33

0.97

1.78

1.48E-02

ccnd2

NM_009829

2.06**

2.04**

1.27

2.30**

0.90

0.84

1.29

0.84

1.21E-02

ccnd2

AK007904

1.99**

0.64*

1.88**

2.62**

1.66*

2.57**

1.00

2.13**

1.28E-03

ccnd2

NM_009829

2.09*

1.00

1.06

2.01*

1.26

0.96

1.12

1.51

2.38E-02

ccnd3

NM_007632

1.26*

0.84

1.54**

1.20

0.81*

2.58**

0.84

3.33**

8.71E-04

ccne1

NM_007633

1.82**

3.37**

7.02**

1.71*

0.94

1.35

1.15

1.82**

2.52E-02

ccne1

BB293079

1.83**

6.68**

1.87**

2.04**

0.85

1.50*

1.16

1.29

1.02E-02

ccne2

AF091432

2.62**

5.86**

5.92**

7.86**

1.74

1.11

1.42

1.39

1.45E-02

cdc2a

NM_007659

0.95

2.91**

11.93**

3.35**

0.51*

1.17

0.89

1.12

4.33E-02

cdc25a

C76119

2.71**

2.23**

2.09**

3.90**

1.11

0.46**

1.07

0.78

1.84E-03

cdc25a

C76119

2.17**

1.73*

2.03**

2.10**

1.02

1.14

1.1

1.21

2.45E-02

cdk4

NM_009870

1.16

0.92

8.41**

1.11

1.32

12.27**

0.74

1.62

2.70E-02

cdk4

NM_009870

1.21

0.74

5.31**

1.5

1.23

11.30**

0.92

1.48

3.31E-02

cdk4

NM_009870

1.20

0.88

5.03**

1.3

1.37

11.17**

0.72

1.37

3.45E-02

cdk7

U11822

0.63*

0.77

3.69**

3.45**

0.82

2.12**

1.09

1.59*

1.37E-02

cks2

NM_025415

0.92

3.03**

10.08**

4.80**

0.51**

0.76

1.27

0.71

4.37E-03

cks2

NM_025415

0.98

2.33**

8.92**

2.34**

0.63*

0.92

0.93

1.32

1.18E-02

pcna

BC010343

1

2.44**

17.91**

4.75**

1.32

3.24**

0.76

3.08**

3.38E-02

pcnt

NM_008787

2.70**

3.79**

5.22**

4.18**

1.14

1.89**

1.10

1.82**

5.43E-06

Cell Cycle Arrest

         

cdkn1a

AK007630

1.57**

2.05**

1.71**

1.24

0.96

1.44*

0.99

0.90

5.01E-03

cdkn1b

NM_009875

1.03

0.19**

0.71

0.95

0.23**

0.42*

0.48*

0.89

1.02E-02

cdkn2a

NM_009877

2.17**

1.79**

1.57**

2.61**

1.21

1.07

1.07

0.87

8.43E-03

cdkn2c

BC027026

0.32**

1.18

5.62**

0.59*

0.85

1.28

0.87

1.60*

9.38E-03

gadd45g

AK007410

0.59*

0.41**

1.88**

0.59**

4.07**

5.16**

3.39**

2.78**

5.95E-03

gas6

NM_019521

0.60**

0.73**

1.02

0.90

1.39**

2.61**

1.43**

5.62**

2.31E-02

ing3

BB298005

0.90

1.12

1.15

0.66**

0.79

0.49**

0.77*

1.34*

1.50E-02

Cell Growth and Cytoskeleton Organization

       

add1

BF140063

0.99

0.96

1.16

0.96

0.85

2.57**

0.86

3.93**

1.94E-02

add1

BF140063

0.82

0.80

0.62**

0.56**

1.25

2.41**

1.24

0.44**

8.01E-03

cap1

NM_007598

4.88*

0.80

1.16

1.14

1.50

8.59**

0.87

0.17**

4.61E-02

cfl1

NM_007687

1.29

0.51**

1.30

1.89**

1.03

2.28**

1.15

2.14**

4.26E-02

creg1

BC027426

1.06

0.83

2.39**

1.72**

0.82

1.54*

0.69*

1.09

3.57E-02

creg1

BC027426

2.08**

2.12**

1.60**

2.16**

0.69*

0.85

0.98

0.92

3.68E-02

egf

NM_010113

1.05

0.79

0.92

1.38*

1.62**

0.47**

0.91

0.84

1.28E-02

lsp1

NM_019391

0.90

0.78*

0.97

1.10

1.02

3.42**

0.67**

1.90**

3.22E-02

myh4

BG794681

0.99

1.25

0.65

1.06

1.72

2.94*

0.94

1.55

8.16E-03

pdlim3

NM_016798

1.00

1.09

1.07

0.78

0.85

2.73**

1.49*

2.29**

4.52E-02

plec1

BM210485

1.31

0.49*

1.25

3.10**

0.53

1.38

1.04

2.87**

2.42E-02

plec1

BM232239

1.20

0.77

1.35

2.46**

3.23**

4.56**

2.82**

0.59*

2.09E-03

tuba3a

NM_009446

0.97

0.97

1.13

1.00

0.83

3.09**

0.89

3.20**

1.22E-02

tubb2c

BC005547

1.06

1.04

4.72**

1.48*

1.13

2.01**

1.04

1.41*

3.23E-02

tubb6

NM_026473

1.21

0.90

2.95**

1.71*

0.97

2.99**

1.28

3.49**

2.41E-02

  1. Selected MYC-responsive genes relating to cell growth and cell proliferation. 'MYC-response p-value' is the p-value identified for the highest-order interaction of the MYC activation variable and represents the significance of this term within the selected model. Flags represent contrast p-values comparing 4OHT-treated and vehicle-treated samples at specific time points ('*', p ≤ 0.05; '**' p ≤ 0.01). Cells are colour-coded based on a detected fold-change greater than 1.5-fold (red, up-regulated; blue, down-regulated)
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