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Table 3 IC50 values for Cp CDPK1 inhibitors tested.

From: The Cryptosporidium parvum Kinome

Compound

IC50 (nM)

1.3 ± 0.2

2.1 ± 0.2

2.1 ± 0.3

2.8 ± 0.2

3.4 ± 0.1

3.4 ± 0.1

0.9 ± 0.1

2.6 ± 0.1

4.7 ± 0.4

7 ± 0.2

5.6 ± 0.5

15.2 ± 4.4

5.6 ± 0.8

7.7 ± 1

22 ± 2

249 ± 73

96 ± 13

88 ± 0.14

616 ± 203

2722 ± 72

  1. All compounds were tested using 500 μM ATP and 500 μM Syntide2 as described in Methods. A concentration range from 1 nM to 1 μM for all compounds was used except for CZ25, CZ15 and 1nA-PP1 (2 nM to 2 μM), CZ27 (4 nM to 4 μM) and JC022 (8 nM to 8 μM).
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BMC Genomics

ISSN: 1471-2164

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