Genomic and proteomic analyses of Mycobacterium bovis BCG Mexico 1931 reveal a diverse immunogenic repertoire against tuberculosis infection

Table 1 Region of difference (RD) profiles in BCG Mexico strains.

BCG	Profile of regions of difference
Substrains	RD1	RD2	RD8	RD14	RD16	RD18	RDD/G	IS6110	DU2
Mexico seed lot 1931	-	-	+	+	+	-	+	+	IV
Phipps	-	-	+	+	+	-	+	+	IV
Tice	-	-	+	+	+	-	+	+	IV
Mexico seed lot 1988	-	-	+	+	+	+	-	+	III
Mexico vaccine 1997	-	-	+	+	+	+	-	+	III
Danish 1331	-	-	+	+	+	+	-	+	III

The symbol (-) indicates the loss of a region in the genome of a given strain, whereas the symbol (+) indicates the presence of the region. RD = region of difference; IS6110 = insertion sequence IS6110 (presence of a single copy); DU = tandem duplication.

ISSN: 1471-2164