Figure 6

Number of False Negatives and False Positives under hypothetical screening scenarios. We assume a false positive rate of 1% and a false negative rate of 10%, a scenario of 100 "true hits" in the library, and a library targeting 13,735 protein-encoding genes. (A) The predicted number of false negatives with 1, 2, or 3 dsRNAs per gene under 3 different rules for interpreting ambiguous cases. (B) The predicted number of false positives with 1, 2, or 3 dsRNAs per gene under 3 different rules for interpreting ambiguous cases.