Table 1 Genes and polymorphisms showing significant summary odds ratio (OR) of the addiction susceptibility from random/fixed-effects meta-analyses using allelic contrasts
From: Meta-analysis and genome-wide interpretation of genetic susceptibility to drug addiction
Gene Name | Polymorphism* | Model (Major allele > Minor Allele) | Cases vs. Controls (independent samples) | Fixed Effects OR (95% CI) | Random Effects OR (95% CI) | Heterogeneity p- Value | I- Square | Grade** |
|---|---|---|---|---|---|---|---|---|
SLC4A7 | rs3278 | G > A | 1410 vs. 906 (3) | 2.34 (1.599-3.420) | 2.28 (1.555-3.333) | 0.51 | 0 | B |
DRD4 | 48-bp repeat | Other > 7/8 repeats | 2324 vs. 1932 (6) | 1.44 (1.155-1.804) | 1.48 (1.000-2.197) | 0.06 | 52 | C |
DRD2/ ANKK1*** | Taq1A | A2 > A1 | 6312 vs. 7424 (20) | 1.30 (1.192-1.410) | 1.38 (1.096-1.733) | < 0.0001 | 84 | C |
BDNF | rs6265 | G > A | 2530 vs. 4126 (9) | 1.31 (1.165-1.451) | 1.38 (1.056-1.790) | < 0.0001 | 80 | C |
CCK | -45 C/T | C > T | 860 vs. 2002 (6) | 1.34 (1.089-1.650) | 1.34 (1.083-1.646) | 0.62 | 0 | B |
FAAH | rs324420 | P > T | 498 vs. 1570 (3) | 1.38 (1.014-1.875) | 1.32 (0.807-2.171) | 0.24 | 28 | B |
OPRM1 | rs1799971 | A > G | 2846 vs. 4072 (9) | 1.24 (1.090-1.410) | 1.31 (0.958-1.790) | < 0.0001 | 80 | C |
COMT | rs4680 | Val > Met | 862 vs. 1594 (3) | 0.76 (0.634-0.923) | 0.82 (0.644-1.051) | 0.71 | 0 | B |
CNR1 | (AAT)n | 14 repeats > Other | 2304 vs. 2144 (8) | 0.76 (0.658-0.878) | 0.75 (0.619-0.906) | 0.17 | 32 | B |
HNMT | rs35953316 | Thr > Ile | 1540 vs. 1306 (3) | 0.76 (0.598-0.975) | 0.72 (0.444-1.179) | 0.04 | 70 | C |
OPRK1 | rs702764 | A > G | 292 vs. 246 (3) | 0.62 (0.431-0.901) | 0.62 (0.412-0.944) | 0.99 | 0 | B |
OPRM1 | C691G | C > G | 796 vs. 786 (3) | 0.52 (0.416-0.647) | 0.61 (0.330-1.095) | 0.0025 | 83 | C |