Figure 2

Growth kinetics of S. pneumoniae wild-type (1974), LNZ-resistant mutant (1974M1) and LNZ-resistant transformants. A. Growth curves of S. pneumoniae 1974 transformed with four mutated copies of 23S rRNA alone (T-7); or along with altered versions of spr0333 (T-7^spr0333); spr1021 (T-7^spr1021); spr1887 (T-7^spr1887); or a combination of the three (T-7^{spr0333, 1021, 1887}). B. Growth curves of S. pneumoniae 1974 transformed with four mutated copies of 23S rRNA alone (T-7); or along with altered versions of spr0188 (T-7^L3); spr0188 and spr0196 (T-7^L3L16); spr0188, spr0196 and spr0333 (T-7^L3L16spr0333); or spr0188, spr0196 and spr1887 (T-7^L3L16spr1887). Data are expressed as the mean of three independent experiments and the statistical significance of the growth differences are indicated in the text.