Variation in chromosome copy number influences the virulence of Cryptococcus neoformans and occurs in isolates from AIDS patients

Table 2 Summary of chromosome changes in second-generation black and white variants collected in culture and from infected mice.

Starting strain/color	Aberrant chromosome	2^nd Generation strain^a/pigment	Aberrant chromosome(s)
Strains collected in culture
White to black
W2/white	Chr 13	W2-BA/black	Chr 13, 4, 12
W2/white	Chr 13	W2-BB/black	Chr 13, 12^b
W3/white	Chr 13	W3-BB/black	Chr 13, 4
W3/white	Chr 13	W3-BC/black	Chr 13, 12
White to white
W2/white	Chr 13	W2-WB/white	Chr 13 (3, 5, 12, 14)^b
Black to white
B1/black	none	B1-WA/white	Chr 3^b, 11^b
B1/black	none	B1-WB/white	Chr 13 (3, 5, 11)^b
B1/black	none	B1-WC/white	Chr 13, 5^b, 6
Strains collected from mice
White to black
W2/white	Chr 13	W2-MB3/black	Chr 13, 4
W2/white	Chr 13	W2-MB4/black	Chr 13, 4
W2/white	Chr 13	W2-MB5/black	none
W2/white	Chr 13	W2-MB7/black	Chr 13, 4, 12
W2/white	Chr 13	W2-MB8/black	Chr 13, 4
W3/white	Chr 13	W3-MB13/black	Chr 4, 14^b
W3/white	Chr 13	W3-MB16/black	none
White to white
W2/white	Chr 13	W2-MW1/white	Chr 13
W2/white	Chr 13	W2-MW2/white	Chr 13
W3/white	Chr 13	W3-MW6/white	Chr 13
Black to white
B6/black	none	B6-MW10/white	none
B6/black	none	B6-MB20/white	none

^aThe second generation strains are named after the starting strain followed by the color (B = black and W = white) and a letter or number designation. In the case of strains collected from mice, an M is added before the letter indicating color.
^bThese chromosomes show segmental changes. Note that some chromosomes show an elevated copy number but not full disomy perhaps indicating variability among cells in the population.

ISSN: 1471-2164