Figure 9
Endothelial adaptive response to moderate hypothermia (25°C/72 h). See Conclusions for details. Thioredoxin (Trx), thioredoxin reductase (TrxR), tyrosine hydroxylase (TH), reduced glutathione (GSH), glutathione S-transferase (GST), protein disulfide isomerase (PDIA1 and 4), reduced protein thiols (P(SH)2), protein disulfide (PSSP), glutathionylated protein (P-SSG), oxidized protein (P-S•), S-adenosylhomocysteine hydrolase (SAHH), peroxiredoxin 1 (Prx1), aldehyde dehydrogenase (ALDH), nicotinamide phosphoribosyltransferase (Nampt), reduced/oxidized nicotinamide adenine dinucleotide phosphate (NADPH/NADP+), fatty acid synthase (FAS), ribonucleotide reductase M1 (RRM1), inosine-5'-monophosphate dehydrogenase 2 (IMPDH2), phosphofructokinase (PFK), pentose phosphate pathway (PPP), histone (H2AV, H2BFC, H2BFQ), histone binding proteins (NASP or nuclear autoantigenic sperm protein), chromatin binding proteins (High-mobility group protein B1 (HMGB1), high-mobility group protein 1-like10 (HMG1L10), barrier to autointegration factor 1 (BANF1)), RNA binding motif protein 3 (RBM3), Y-box binding protein 1 (YB-1), cold-shock domain protein A (CSDA), prohibitin (PHB), enolase 1 (ENO1), lethal(3)malignant brain tumor-like 2 protein (L3MBTL2), heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL), Zinc finger protein 224 (ZNF224).