From: Comparative analysis and assessment of M. tuberculosis H37Rv protein-protein interaction datasets
Source PPIs for homology transfer | STRING database experimental PPIs (with other prediction support) | ||
---|---|---|---|
Identify homology and transfer | PIDE >30 | HVAL >20 | Orthologues |
Coverage >0.2 | E-value <1*e-6 | Identified by inparanoid (default parameters) | |
E-value< 1*e-10 | |||
Benchmark | M. tuberculosis H37Rv high-throughput B2H PPIs dataset | ||
Jaccard coefficient | 0.00485 | 0.00225 | 0.00359 |
Precision | 0.00507 | 0.00267 | 0.00401 |
Recall | 0.100 | 0.0563 | 0.0331 |
Overlapping PPIs | 5 | 4 | 4 |
Benchmark | M. tuberculosis H37Rv predicted functional associations datasetfrom STRING database (with PPIs score above 770) | ||
Jaccard coefficient | 0.365 | 0.233 | 0.186 |
Precision | 0.467 | 0.314 | 0.365 |
Recall | 0.625 | 0.473 | 0.275 |
Overlapping PPIs | 651 | 828 | 524 |