Figure 2

Change point comparison between the given and redefined cutoffs for endpoint F. A. Change point comparison. Two parts in the figure; the upper one is for posterior mean, and the lower part for the posterior probability. In the upper part, the blue solid lines and the translucent skew ellipses refer to the change point chart of the cutoff 730 days (2*365) given by MAQC-II project, while the others refer to the change point chart with the redefined cutoff 1,561. Posterior mean for the given cutoff is linear scaled to the range of that for the redefined cutoff. The boxplot in the left side of the change point charts represent the ranges of the first component values of the OS negative samples. The larger points represent the unpredictable samples. The skew elliptical ones in purple and the circle ones in orange represent the corresponding positions in the charts with given cutoff and redefined cutoff, respectively. In the posterior probability part of the figure, the dashed lines are the reference lines of the maximum posterior probability values. B. Kaplan-Meier survival curve. Six Kaplan-Meier survival curves are shown in the figure for six datasets, including training, test and training-test combined dataset for both EFS and OS endpoint. Three EFS associated curves (blue, green, wheat) are more sloping than OS associated curves (purple, yellow, red) and underneath the OS associated curves.