TCS Cluster | TCS protein | GenBank Locus Tag | Functions | References |
---|---|---|---|---|
TCS-1 | HK-VicK RR-VicR | SMU.1516 SMU.1517 | Biofilm development, competence development, oxidative stress tolerance, acid tolerance, autolysin production, glucan metabolism, fructan metabolism. | |
TCS-2 | HK-CiaH RR-CiaR | SMU.1128 SMU.1129 | Sucrose-dependent biofilm formation, competence development, multiple stress response, bacteriocin production | |
TCS-3 | HK-CovS RR-CovR | SMU.1145 SMU.1146 | Acid tolerance, hydrogen peroxide resistance, murine macrophage killing. | |
TCS-4 | HK-KinF RR-LlrF | SMU.928 SMU.927 | Acid tolerance, pp(G)pp metabolism, control of alarmone synthesis. | |
TCS-5 | HK- ScnK RR- ScnR | SMU.1814 SMU.1815 | Bacteriocin production*. | [49]* |
TCS-6 | HK- SpaK RR- SpaR | SMU.660 SMU.659 | Bacteriocin production*, self-protection against anti-microbial peptides*. | |
TCS-7 | HK- PhoR RR-YcbL | SMU.1037 SMU.1038 | Unknown. | Â |
TCS-8 | HK-KinG RR-LlrG | SMU.1009 SMU.1008 | Bacteriocin resistance, substrate transport in cell envelope stress. | |
TCS-9 | HK-LevS RR-LevR | SMU.1965 SMU.1964 | Biofilm formation, acid tolerance, fructan metabolism. | |
TCS-10 | HK-LytS RR-LytT | SMU.577 SMU.576 | Biofilm formation, oxidative stress tolerance, autolysis, fructan metabolism, cell wall metabolism*. | |
TCS-11 | HK-LiaS RR-LiaR | SMU.486 SMU.487 | Biofilm formation, acid tolerance, cell envelope stress response, bacteriocin production, bacteriocin resistance, sucrose-dependent adherence. | |
TCS-12 | HK-HK11 RR-RR11 | SMU.1548 SMU.1547 | Unknown. | Â |
TCS-13 | HK-ComD RR-ComE | SMU.1916 SMU.1917 | Biofilm formation, quorum sensing, competence development, bacteriocin production. | |
TCS-14 | HK RR | SMU.45 SMU.46 | Unknown. | Â |
Orhpan RR1 | RR-GcrR | SMU.1924 | Sucrose-dependent adherence, glucan metabolism, pH homeostasis, competence development. |