Figure 6

Overview of prominent metabolic and medically relevant features of C. resistens DSM 45100 deduced from the complete genome sequence. Metabolic features associated with carbohydrate metabolism, histidine utilization, sulfate reduction, fatty acid metabolism, mycolic acid biosynthesis, and pilus formation are shown. Relevant proteins assigned to these processes are labeled by yellow boxes; relevant transport systems are shown as blue circles. The predicted virulence factors are probably secreted by the machinery of the general secretory pathway (Sec system). The role of the predicted virulence factors in ensuring the availability of exogenous fatty acids for growth of C. resistens is remarkable. The presence of pJA144188 in C. resistens DSM 45100 is indicated and the encoded antibiotic resistance proteins are listed. The role of the Tet(W) protein in ribosomal protection of C. resistens DSM 45100 is highlighted, as it is most likely responsible for the clinically relevant resistance to minocycline.