Figure 1

(A) Whole genome view of chromosomal aberrations of 15 melanoma cell lines. Vertical lines represent individual samples. Segments are defined by amplifications (red), deletions (blue), and regions unchanged with respect to diploid reference (green) (B) Chart showing comparisons between select oncogenes and tumor suppressors in 15 melanoma cell lines compared to data published by Gast et al. [23]. Asterisks denote genes where copy number state of gene was mixed, and a visual diagram of this phenomenon is illustrated in panel C. (C) Examples of 2 genes that showed copy number aberrations intra-gene. CDKN2A showed 38% unchanged/62% deletion in 1 sample. CDK4 showed 53% unchanged/47% amplification in 3 samples, and 53% deletion/47% amplification in 1 sample.