Table 1 Funspec classification into biological process categories of genes up- or downregulated in response to changes in the oxidation of NADPH and NADH

f

Upregulated genes

10

alcoholic metabolic bioprocess GO:0006066

BDH1 ADH7

BDH1

BDH1 ADH7

BDH1 ADH7

196

response to stress GO:0006950

PAU24 PAU14 PAU1

PAU7 PAU24 PAU3 PAU10 PAU2 PAU11 PAU12 PAU13 PAU14 PAU15 PAU1 PAU17 PAU18 PAU23 PAU4 PAU6 MET22 PAU20 FRT1

PAU7 PAU2 PAU14 PAU17 PAU4 MET22 ZEO1 PAU20

511

translation GO:0006412

RPL31A RPS16B RPS17B RPL27B RPL23B RPL30 RPL24A RPL24B RPL40B RLP24 RPS31 RPS25B RPS22B RPS17A RPL15B RPL9B RPS3 RPS19A RPL25 RPS28A RPL20B RPL33A

41

methionine biosynthetic process GO:0009086

MET10 MET17

MET6 MET3 MET14 MET17 MET22 MET16

MET6 MET10 MET5 MET14 MET17 MET22 MET16

10

L-serine biosynthetic process GO:0006564

SER3

SER3 SER33

12

lysine biosynthetic process GO:0009085

LYS12 LYS9

LYS12 LYS9

hydrogen sulfide biosynthetic process GO:0070814

CYS4

561

oxidation reduction GO:0055114

BDH1 ADH7 MET10 ARI1 ERG3 AHP1 AAD15

BDH1 ADH7 AAD3 YDR541C SER3 MET10 ARI1 GND1 SER33 LYS12 MET5 MDH1 LYS9 AAD15 IDH2 MET16

10

pentose-phosphate shunt GO:0006098

SOL3 GND1

SOL3 GND1 TAL1 TKL1

19

cofactor metabolic process GO:0051186

MDH1 IDH2

9

glucose catabolic process to ethanol GO:0019655

PDC5

Downregulated genes

8

fermentation GO:0006113

ADH4

ADH4

ADH4

129

vacuolar protein catabolic process GO:0007039

PEX29 HXK1 STF2 TFS1 PGM2 DDR48 GPH1

9

glucose catabolic process to ethanol GO:0019655

PDC1 PDC5

322

translational elongation GO:0006414

ZRT1 PRY1 TPO1 AGA1 WHI5 PDR12 SAM3

THI2 ZRT1 QDR2 PRY1 IZH2 WHI5 PDR12 SAM3

103

carbohydrate metabolic process GO:0005975

EMI2 HXK1 PGM2 GPH1