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Table 2 Significantly differentially expressed genes in acute phase response

From: RNA-seq liver transcriptome analysis reveals an activated MHC-I pathway and an inhibited MHC-II pathway at the early stage of vaccine immunization in zebrafish

Gene name

Accession number

Description

RPKM-C

RPKM-V

Fold-change

p-value

ahsg

ENSDARG00000069293

Alpha-2-HS-glycoprotein

554.80

55.81

−11.84

7.26E-50

apoa4

ENSDARG00000040298

Apolipoprotein A-IV

266.33

164.60

−2.09

2.21E-04

tfrc

ENSDARG00000012552

Transferrin receptor (p90, CD71)

23.29

13.29

−2.27

1.18E-04

c1qb

ENSDARG00000044612

Complement component 1, q subcomponent

6.06

3.14

−2.23

6.06E-03

plg

ENSDARG00000023111

Plasminogen

64.66

37.99

−2.18

6.73 E-04

aerping1

ENSDARG00000058053

C1 inhibitor

15.69

6.71

−2.93

5.49E-05

c2

ENSDARG00000019772

Complement component 2

24.57

52.88

2.06

2.99E-10

si:dkey-8 k3.2

ENSDARG00000038424

Complement C4

323.79

978.12

2.07

8.93E-13

cfb

ENSDARG00000055278

Complement factor B

727.97

1914.46

2.09

3.38 E-03

apcs

ENSDARG00000045089

Serum amyloid P component

309.74

872.88

2.16

1.64 E-04

cp

ENSDARG00000010312

Ceruloplasmin (Fragment)

633.50

1737.21

2.19

2.74 E-03

c9

ENSDARG00000016319

Complement component C9

18.78

48.27

2.28

4.90E-157

cfhl2

ENSDARG00000056778

Complement factor H, like 2

11.76

38.65

2.28

6.44E-07

tfr2

ENSDARG00000089980

Transferrin receptor 2

10.84

34.09

2.51

2.58 E-04

fga

ENSDARG00000020741

Fibrinogen alpha chain

375.41

1118.34

2.55

4.87E-05

c3a

ENSDARG00000012694

Complement component c3a

1305.16

4584.02

2.77

1.21 E-03

serpina7

ENSDARG00000087143

Antitrypsin

466.41

1720.58

3.05

1.18E-05

c3

ENSDARG00000043719

PREDICTED: complement C3-H2-like

154.97

692.50

3.44

1.19E-08

serpine1

ENSDARG00000056795

Plasminogen activator inhibitor type 1

13.14

68.84

4.38

6.20E-14

cebpb

ENSDARG00000042725

CCAAT/enhancer binding protein, beta

37.33

202.58

4.42

4.58E-13

fgg

ENSDARG00000037281

Fibrinogen, gamma polypeptide

154.90

965.71

5.39

6.08E-15

fth1a

ENSDARG00000015551

Ferritin

180.30

1233.87

5.45

9.51E-14

f2r

ENSDARG00000060012

Coagulation factor II (Thrombin) receptor

0.38

3.11

6.57

6.63E-05

si:ch211-234p6.7

ENSDARG00000071456

C-reactive protein

0.37

3.41

9.71

2.46 E-04

atp7a

ENSDARG00000003699

ATPase, Cu++ transporting

0.21

3.99

13.09

2.38E-06

hpx

ENSDARG00000051912

Hemopexin

192.84

7565.38

31.36

3.57E-17

tlr5b

ENSDARG00000052322

Toll-like receptor 5

2.17

98.99

36.41

7.93E-62

lygl1

ENSDARG00000056874

Lysozyme

11.85

641.71

41.37

1.70E-41

c7

ENSDARG00000057121

Complement component 7

6.38

435.85

63.02

4.13E-36

itln3

ENSDARG00000003523

Intelectin 3

52.98

8467.17

129.02

3.93E-33

lect2l

ENSDARG00000033227

Leukocyte cell-derived chemotaxin 2

8.75

2597.52

222.85

8.92E-56

hp

ENSDARG00000051890

Haptoglobin

14.36

7332.05

387.28

1.97E-30

saa

ENSDARG00000045999

Serum amyloid protein A

1.24

1248.94

883.07

2.56E-66

  1. Identification of all differentially expressed genes was based on p < 0.05. A p-value < 0.05 indicated that the gene was significantly altered in WED immunized fish with respect to mock-immunized fish. The absolute value of “Fold-change” is the magnitude of up- or down-regulation for each gene/homolog after WED immunization. Fold-change > 2 indicates up-regulation, and < −2 indicates down-regulation.
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BMC Genomics

ISSN: 1471-2164

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