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Table 2 Top 25 GO categories overrepresented in SI of SPF mice compared to GF mice

From: A microarray analysis of gnotobiotic mice indicating that microbial exposure during the neonatal period plays an essential role in immune system development

GOID

Term

Number of Probes

p_int

GO:0015992

proton transport

67

< 1.0E-18

GO:0015986

ATP synthesis coupled proton transport

44

< 1.0E-18

GO:0006099

tricarboxylic acid cycle

39

< 1.0E-18

GO:0016192

vesicle-mediated transport

95

< 1.0E-18

GO:0006631

fatty acid metabolic process

63

< 1.0E-18

GO:0045454

cell redox homeostasis

46

1.11E-16

GO:0006754

ATP biosynthetic process

40

2.78E-15

GO:0006096

Glycolysis

56

5.32E-13

GO:0016481

negative regulation of transcription

68

1.05E-12

GO:0042254

ribosome biogenesis and assembly

96

2.27E-11

GO:0009987

cellular process

85

2.41E-11

GO:0001501

skeletal development

27

3.77E-11

GO:0006461

protein complex assembly

52

3.84E-11

GO:0021799

cerebral cortex radially oriented migration

5

5.23E-11

GO:0021813

cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex glial-mediated radial cell migration

5

5.23E-11

GO:0021589

cerebellum structural organization

5

5.23E-11

GO:0021942

radial glia guided migration of Purkinje cell

5

5.23E-11

GO:0000160

two-component signal transduction system (phosphorelay)

31

6.78E-11

GO:0008654

phospholipid biosynthetic process

41

1.00E-10

GO:0007031

peroxisome organization and biogenesis

20

4.44E-10

GO:0007399

nervous system development

96

7.76E-10

GO:0044267

cellular protein metabolic process

26

1.06E-09

GO:0006396

RNA processing

75

1.15E-09

GO:0007162

negative regulation of cell adhesion

11

2.04E-09

GO:0007266

Rho protein signal transduction

38

2.27E-09

GO:0007229

integrin-mediated signaling pathway

36

8.14E-05

  1. MGP analysis was performed on GO BP categories which contains 4 ~ 99 genes (“Number of Probes”). The categories were sorted according to the integrated p value (p_int) and top 25 are represented. The categories related to energy cycle are noted (e.g., “proton transport”, “tricarboxylic acid cycle”, “ATP biosynthetic process”, and “Glycolysis”).