Table 4 Lipid metabolism genes differentially expressed in the liver of fish having high or low flesh n-3 LC-PUFA contents
Probe name | Gene | High/Low LC-PUFA | p- value | |
|---|---|---|---|---|
| Â | Â | L Lipid (LH/LL) | H Lipid (HH/HL) | Â |
Cholesterol biosynthesis, metabolism and regulation | ||||
Omy#S15288895 | Sterol-C4-methyl oxidase-like | 1.84 | 1.32 | 0.0033 |
Ssa#STIR00031_3 | 7-dehydrocholesterol reductase (7dchr) | - 1.55 | - 1.48 | 0.0036 |
Ssa#S30286041 | 7-dehydrocholesterol reductase (7dchr) | - 1.48 | - 1.42 | 0.0120 |
Omy#CF752841 | Sterol regulatory element-binding transcription factor 2 (srebp2) | - 1.71 | - 1.31 | 0.0170 |
Ssa#TC102141 | Cytochrome P450, family 27, subfamily A, polypeptide 1 | - 3.97 | - 1.04 | 0.0192 |
Ssa#STIR16974 | 7-dehydrocholesterol reductase (7dchr) | - 1.46 | - 1.31 | 0.0195 |
Ssa#AM402497 | Hydroxymethylglutaryl-CoA synthase 1 | - 2.39 | 1.21 | 0.0199 |
Ssa#STIR00031_4 | 7-dehydrocholesterol reductase (7dchr) | - 1.41 | - 1.46 | 0.0212 |
Ssa#STIR00098_4 | Isopentenyl-diphosphate delta isomerise (ipi) | - 2.12 | - 1.15 | 0.0228 |
Ssa#S18867829 | 7-dehydrocholesterol reductase (7dchr) | - 1.33 | - 1.25 | 0.0228 |
Ssa#DY741343 | Lanosterol 14-alpha demethylase | - 1.42 | - 1.28 | 0.0346 |
Omy#S22913656 | Acetoacetyl-CoA synthetase | - 1.77 | - 2.52 | 0.0358 |
Ssa#STIR00033_3 | Mevalonate kinase (mev) | - 1.54 | - 1.08 | 0.0393 |
Ssa#CA064135 | Vigilin | 2.80 | - 1.22 | 0.0423 |
Ssa#DW582478 | Cytochrome P450, family 8, subfamily B, polypeptide 1 | - 1.26 | - 1.50 | 0.0449 |
Ssa#STIR00102_3 | Squalene epoxidase | - 2.11 | - 1.36 | 0.0468 |
Glycerophospholipid synthesis | ||||
Ssa#STIR39152_S | Lipid phosphate phosphohydrolase 2 (lpp2) | 1.20 | 1.19 | 0.0177 |
Ssa#KSS4003 | Chka protein | 1.18 | 1.53 | 0.0264 |
Ssa#S35538062_S | Monoacylglycerol O-acyltransferase 1 (mgat) | 1.20 | 1.51 | 0.0303 |
Ssa#S31963704 | Diacylglycerol O-acyltransferase homolog 2 | 1.41 | 1.02 | 0.0358 |
Ssa#S48418830 | Phosphatidylglycerophosphate synthase 1 | - 1.52 | - 1.72 | 0.0369 |
Fatty acid synthesis | ||||
Ssa#KSS4155 | Trans-2-enoyl-CoA reductase, mitochondrial precursor | - 1.26 | - 1.25 | 0.0440 |
Intracellular fatty acid transport | ||||
Ssa#S35585414 | Acyl-CoA-binding protein | 10.47 | 1.65 | 0.0081 |
Ssa#DY703528 | Fatty acid-binding protein, intestinal | - 1.25 | - 1.46 | 0.0331 |
Ssa#CB509140 | Fatty acid-binding protein, intestinal | - 1.20 | - 1.35 | 0.0375 |
Ssa#STIR04578 | Fatty acid-binding protein, heart | 1.22 | 1.47 | 0.0401 |
Lipid transport | ||||
Ssa#CK898816 | Low density lipoprotein receptor-related protein 1 (lrp1) | - 1.14 | - 1.39 | 0.0341 |
Ssa#S32008850 | Apolipoprotein A-IV precursor (apoa4a) | - 1.43 | - 1.01 | 0.0377 |
Omy#BX318293 | Low density lipoprotein receptor-related protein 1 (lrp1) | - 3.61 | - 1.67 | 0.0404 |
Ssa#S18866963 | Apolipoprotein A-IV precursor (apoa4b) | - 1.39 | - 1.43 | 0.0428 |
Lipid hydrolysis | ||||
Ssa#S18887340 | Acyl-coenzyme A thioesterase 5 | 1.64 | 1.18 | 0.0007 |
Ssa#STIR02708 | Isoamyl acetate-hydrolyzing esterase 1 homolog | 1.54 | 1.12 | 0.0013 |
Ssa#DW007099 | Similar to patatin-like phospholipase domain containing 7 | - 3.75 | - 2.37 | 0.0070 |
Ssa#S31963297 | Acyl-CoA thioesterase 11 | 1.35 | 1.38 | 0.0097 |
Ssa#STIR07750 | N-acylsphingosine amidohydrolase 1 | - 1.14 | - 1.34 | 0.0122 |
Ssa#STIR05034 | Isoamyl acetate-hydrolyzing esterase 1 homolog | 1.74 | 1.01 | 0.0208 |
Omy#CA366823 | Acyl-coenzyme A thioesterase 3 | 1.33 | 2.17 | 0.0248 |
Ssa#STIR22551 | Lipoprotein lipase (lpl) | 1.31 | 1.31 | 0.0346 |
Eicosanoid synthesis and metabolism | ||||
Ssa#TC68569 | Thromboxane-A synthase (thas) | - 1.33 | - 1.67 | 0.0269 |
Ssa#TC110080 | Phospholipase A2 (pla2g4) | 1.26 | 1.08 | 0.0296 |
Omy#TC147730 | Prostaglandin I2 (prostacyclin) synthase (ptgis) | - 2.53 | - 4.25 | 0.0349 |
Ssa#S35581706 | 15-hydroxyprostaglandin dehydrogenase | - 1.51 | - 1.09 | 0.0400 |
Ssa#EG930234 | Arachidonate 5-lipoxygenase (alox5) | 1.91 | 1.55 | 0.0449 |
Regulation of lipid metabolism | ||||
Ssa#TC112002 | Retinoid X receptor beta | 1.00 | - 19.09 | 0.0000 |
Ssa#KSS2129 | Adiponectin receptor protein 1 | - 1.30 | - 1.31 | 0.0098 |
Ssa#CA056493 | Angiopoietin-like 6 | - 1.63 | - 1.07 | 0.0290 |
Ssa#S35490606 | Adiponectin, C1Q and collagen domain containing, like | 1.34 | 1.66 | 0.0441 |
Ssa#S18888608 | Adiponectin receptor protein 1 | - 1.38 | - 1.40 | 0.0451 |