Figure 3
From: LRpath analysis reveals common pathways dysregulated via DNA methylation across cancer types
Hypermethylation in the KCNA3 promoter region across multiple cancer types. Voltage gated channel activity is highly enriched with hypermethylated genes. The silencing of potassium voltage-gated channel, shaker-related subfamily, member 3 (KCNA3) via promoter methylation has been reported in breast and pancreas tumors. Here, we observe KCNA3 promoter methylation as a prevalent event across multiple cancer types including lung, ovarian, kidney, prostate, and colon. FDR levels were calculated using LIMMA package as described in methods.