Table 3 List of the top 10 genes with an expression decrease in milk somatic cells due to intra-mammary infection with S. aureus

T4

SPP1

secreted phosphoprotein 1

Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity (By similarity)

−2.4

ABCG2

ATP-binding cassette, sub-family G (WHITE), member 2

Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123

−2.1

CD24

CD24 molecule

Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells

−2.0

KRT19

keratin 19

Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle

−2.0

EXOSC2

exosome component 2

Component of the exosome 3′->5′ exoribonuclease complex, a complex that degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3′ untranslated regions. Required for the 3′processing of the 7S pre-RNA to the mature 5.8S rRNA. Has a 3′-5′ exonuclease activity

−1.9

HDAC10

histone deacetylase 10

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes

−1.9

C5ORF56

chromosome 5 open reading frame 56

Homo sapiens chromosome 5 open reading frame 56 (C5orf56), mRNA

−1.9

ELF5

E74-like factor 5 (ets domain transcription factor)

Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation

−1.8

MID2

midline 2

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to microtubular structures in the cytoplasm.

−1.8

REG3G

RNA binding motif protein 5

Might be a stress protein involved in the control of bacterial proliferation (By similarity)

−1.8

T5

FASN

fatty acid synthase

Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein

−2.1

CCNB2

cyclin B2

Essential for the control of the cell cycle at the G2/M (mitosis) transition

−1.5