Euchromatin islands in large heterochromatin domains are enriched for CTCF binding and differentially DNA-methylated regions

Table 1 Overlap of EIs with CpG islands (CGIs) and transcription start sites (TSSs)

Cell line	Number of EIs	Average Size of EIs (bp)	% of EIs overlap CGIs (En.^b, P^c)	% of EIs overlap TSSs (En.^b, P^c)	# of genes associated with EIs^a
H1	1,060	4880	9.7 (1.3, 0.06)	7.9 (5.0, <10^-3)	119
ADA-38	758	4401	4.7 (0.6, 0.99)	4.6 (2.7, <10^-3)	60
HA	2,254	5029	14.2 (1.8, <10^-3)	12.4 (7.8, <10^-3)	338
HAEC	2,359	5867	13.6 (1.6, <10^-3)	11.3 (5.4, <10^-3)	373
HPF	2,465	5477	17 (2.1, <10^-3)	12.7 (6.5, <10^-3)	409

^a 1 kb up and downstream of TSS overlapping EIs; ^b Enrichment compared to random patterns; ^c p values calculated by 1,000 permutations.

ISSN: 1471-2164