Figure 4
From: Molecular characterisation of cell line models for triple-negative breast cancers
BC cell lines recapitulate recurrent triple-negative BC-specific amplicons and their possible drivers. Matched heatmaps of gene expression and aCGH within regions of recurrent amplification in BC cell lines (A) and (B). Cell lines were split into those with amplification (AMP) and those without (NA). Heatmap of aCGH (left) shows amplification in red, deletion in green and no change in black for each corresponding chromosomal location of the respective gene. Expression heatmap (middle) indicates if expression values for the gene are above (red) or below (green) the median value. Barplots (right) illustrate of a Pearson’s correlation analysis between expression and DNA copy number levels. Black dotted lines show adjusted P_value threshold of 0.05.