Figure 1
Analysis of Growth Conditions in Oxygen-controlled Fermenter. A) Growth (increase in mycelial dry weight) and glucose consumption (in g/L) of Aspergillus fumigatus during hypoxic cultivation in an oxygen-controlled fermenter. B) Analysis of the pH and the concentration of D/L-lactate, acetate and ethanol (in mM) in the culture supernatant. Data of three fermentation runs are shown. Three liters of AMM was inoculated with 2 × 109 conidia. After a pre-cultivation period under normoxic growth conditions (21% pO2) oxygen supply was shifted to low oxygen levels (0.21% pO2) and samples were taken after 0, 2 (microarray) or 3 (proteomics), 6, 12 and 24 hours.