Figure 8

Transcription factor DNA binding motifs proximal to PPARβ/δ binding regions. (A) Enrichment of transcription factor binding motifs proximal to PPARβ/δ binding regions observed in the absence (DMSO) or presence (GW0742) of exogenous ligand, or with the different response types (I-III) are shown. Values represent the percentage of binding regions containing the indicated transcription factor DNA binding motif. The indicated consensus transcription factor DNA binding motifs are also shown. (B) Sequence similarities between the transcription factor DNA binding motifs were identified by multiple sequence alignments and are shown in a phylogenetic tree. The parentheses indicate the two most common families observed (CREB/ATF/AP1 and ETS).