Skip to main content

Table 1 Glioma tumor suppressors [Roopra]

From: A REST derived gene signature stratifies glioblastomas into chemotherapy resistant and responsive disease

Gene symbol

Correlation

RE1 Site

ChiP

Summary

NF1

p<0.000005

Intronic-TCTAGAACCAAGGCCAG

Abrajano

RasGAP tumorsuppressor. Loss of NF1 by mutation or degradation occurs in many gliomas and is associated with chemotherapy resistance

BEX1

p<10^-16

Intronic-TCTAGAACCAAGGCCAG

Johnson

Suppresses growth of glioma xenografts, reintroduction of BEX1 in glioma cell lines induces chemotherapy sensitivity

CDKN1B/p27KIP1

p<10^-9

Upstream-TCTAGAACCAAGGCCAG

-

Glioma tumor suppressor known to regulate cell growth, apaptosis and sensitivity to chemotherapy

mIR-124

p<10^-29

Multiple

Conaco

Glioma tumor suppressor that regulates proliferation and differentiation

  1. REST ChIP Data are cited from either Abrajano et al [(2009),] Johnson et al [(2007)] or Conaro et al (2006)[[27]].
Back to article page

BMC Genomics

ISSN: 1471-2164

Contact us