Table 3 Key cytokine and signaling pathway elicited in response to CBHA at 6h and 24h in H9c2 cells*
Control versus CBHA (6 h) | Control versus CBHA (24 h) | ||
|---|---|---|---|
Gene pathway | Total connections (No. of focus genes) | Gene pathway | Total connections (No. of focus genes) |
TNF | 45 (22) | CDKN1A | 65 (35) |
Myc | 43 (18) | TP53 | 60 (35) |
HNF4A | 32 (18) | IL-6 | 50 (34) |
PTEN-PI3K-Akt | 76 (17) | HNF4A | 41 (30) |
ERK-p38-JNK | 73 (17) | CDKN2A | 43 (25) |
NFκΒ | 40 (16) | ERK- p38-JNK | 52 (21) |
IFNγ | 45 (12) | NFκΒ | 41 (17) |
FOS | 43 ( 8 ) | IFNγ | 38 (17) |
AP1 | 31 ( 8 ) | Cyclin A | 29 (12) |
Insulin | 28 ( 8 ) | PI3K-Akt | 41 (10) |
TP73 | 16 ( 7 ) | MAPK | 24 ( 8 ) |
CDKN2A | 20 ( 5 ) | Insulin | 24 ( 5 ) |