Figure 2

Functional profiling of genetic modifiers identified in diverse screens. Comparative analysis of modifiers identified in worm (Ce) models of polyQ, tau, SOD and α-synuclein aggregation, yeast (Sc) models of misfolded α-synuclein and Htt toxicity and fly (Dm) models of misfolded tau and polyQ toxicity from diverse screens reveals that the identified modifier genes function in a wide variety of biological processes as defined in the original studies. The blue filled box indicates that one or more genes in this category were identified. The number of the study indicated refers to the numbering in Table 1.