Study Number | Primary model Organism | Disease model | Expressed construct | Screen | Number of Genetic modifiers | Orthologues in C. elegans | Reference |
---|---|---|---|---|---|---|---|
1 | C. elegans | P | Htt-Q0, Q24, Q33, Q35, and Q40 | Genome-wide RNAi | 186 | 186 | [10] |
2 | C. elegans | SOD | G85R SOD | Genome-wide RNAi | 81 | 81 | [11] |
3 | C. elegans | S | WT α-synuclein | Genome-wide RNAi | 82 | 82 | [9] |
4 | C. elegans | T | Tau P301L and V337M | Genome-wide RNAi | 75 | 75 | [14] |
5 | C. elegans | S | WT α-synuclein | Hypothesis-driven RNAi | 20 | 20 | [65] |
6 | C. elegans | P | Htt-Q150 | Candidate genes | 12 | 12 | [37] |
7 | C. elegans | S | WT α-synuclein | Systematic RNAi screen | 11 | 11 | [68] |
8 | C. elegans | P | Htt-Q128 | Candidate genes | 4 | 4 | [13] |
9 | C. elegans | Aβ | Aβ1-42 | Candidate genes | 2 | 2 | [69] |
10 | C. elegans | T | Tau P301L and V337M | Forward genetic | 2 | 2 | [70] |
11 | C. elegans | T | Tau V337M | Candidate genes | 2 | 2 | [71] |
12 | C. elegans | P | Htt-Q32, Q40, Q56, Q79 | Candidate genes | 2 | 2 | [72] |
13 | C. elegans | P | Htt-Q2 and Q150 | Candidate genes | 1 | 1 | [12] |
14 | S. cerevisiae | P and S | Htt-Q20, Htt-Q53, A53T α-synuclein | Genome-wide genetic | 138 | 41 | [24] |
15 | S. cerevisiae | S | α-synuclein | Selected genetic screen | 77 | 20 | [73] |
16 | S. cerevisiae | Aβ | Aβ1-42 | Genome-wide genetic | 40 | 11 | [60] |
17 | S. cerevisiae | P | Htt-Q103 | Genome-wide loss-of-function suppressor | 30 | 5 | [50] |
18 | S. cerevisiae | S | WT α-synuclein | Genome-wide overexpression | 22 | 7 | [58] |
19 | S. cerevisiae | S | WT α-synuclein | Candidate genes | 5 | 1 | [59] |
20 | D. melanogaster | T | Tau V337M | Large-scale genetic | 30 | 14 | [74] |
21 | D. melanogaster | P | Htt-Q128 | protein interaction and selected genetic screen | 32 | 34 | [75] |
22 | D. melanogaster | P | SCA1 82Q and Htt-Q128 | Selective genetic modifier screen | 24 | 20 | [34] |
23 | D. melanogaster | T | Tau V337M | Large-scale genetic | 24 | 10 | [76] |
24 | D. melanogaster | P | Htt-Q127 | Selective genetic modifier screen | 10 | 2 | [77] |
25 | D. melanogaster | P | SCA3trQ78 | Genome-wide screen | 18 | 17 | [63] |
26 | D. melanogaster | P | SCA1 30Q and 82Q | Large-scale genetic | 17 | 11 | [78] |
27 | D. melanogaster | P | Htt-Q127 | Genome-wide screen | 2 | 1 | [79] |
28 | D. melanogaster | S | A30P and A53T α-synuclein | Candidate gene | 1 | 1 | [80] |
Total | Â | Â | Â | Â | 950 | 675 | Â |