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Table 3 Mediators of inflammation and articular damage up-regulated in DA synovium and down-regulation in DA.F344(Cia5a)

From: The arthritis severity locus Cia5a regulates the expression of inflammatory mediators including Syk pathway genes and proteases in pristane-induced arthritis

Gene Symbol

Gene Name

Entrez Gene ID

Fold DA/Cia5a

p-value*

Cytokines and chemokines

    

Il1b

interleukin 1 beta

24494

5.17

0.002

Il18

interleukin 18

29197

3.91

0.0002

Ltb

lymphotoxin beta

361795

3.77

0.0002

Mif

macrophage migration inhibitory factor

81683

2.37

0.0002

Aif1

allograft inflammatory factor 1

29427

2.48

0.0001

Ccl2

chemokine (C-C motif) ligand 2

24770

3.95

0.01

Ccl7

chemokine (C-C motif) ligand 7

287561

7.90

0.002

Cxcl1

chemokine (C-X-C motif) ligand 1

81503

10.88

0.0004

Cxcl13

chemokine (C-X-C motif) ligand 13

498335

7.53

0.000004

Proteases

    

Mmp3

matrix metallopeptidase 3

171045

23.94

0.0001

Mmp9

matrix metallopeptidase 9

81687

32.79

0.000000001

Mmp14

matrix metallopeptidase 14

81707

4.46

0.000000004

Mmp19

matrix metallopeptidase 19

304608

5.63

0.0000003

Ctsc

cathepsin C

25423

2.64

0.00007

Ctsd

cathepsin D

171293

1.90

0.000002

Ctse

cathepsin E

25424

2.03

0.0002

Ctsk

cathepsin K

29175

3.20

0.0000003

Ctss

cathepsin S

50654

1.68

0.002

Extra-cellular matix

    

Cthrc1

collagen triple helix repeat containing 1

282836

17.93

0.000000003

Col12a1

collagen, type XII, alpha 1

25683

16.25

0.00000008

Emilin1

elastin microfibril interfacer 1

298845

13.55

0.000002

Adhesion molecules

    

Itga5

integrin alpha 5 (fibronectin receptor alpha)

315346

3.47

0.00000001

Itgam

integrin alpha M

25021

3.58

0.0001

Itgav

integrin alpha V

296456

1.61

0.0004

Itgb2

integrin beta 2

309684

3.44

0.0001

Itgb7

integrin, beta 7

25713

3.86

0.002

Cd44

Cd44 molecule

25406

1.83

0.005

Cdh11

cadherin 11

84407

1.87

0.003

 

Toll-like receptors and regulators of their activity

Cd14

CD14

60350

2.13

0.001

Irak4

interleukin-1 receptor-associated kinase 4

300177

1.65

0.0004

Lpb

lipopolysaccharide binding protein

29469

4.36

0.0003

Myd88

myeloid differentiation primary response gene 88

301059

1.59

0.002

Pycard

PYD and CARD domain containing

282817

1.95

0.0004

Tlr2

toll-like receptor 2

310553

4.36

0.000

Tlr6

toll-like receptor 6

305353

1.76

0.001

 

Prostaglandin and leukotriene synthesis

Ptgs2

prostaglandin-endoperoxide synthase 2

29527

9.73

0.0006

Pla2g4a

phospholipase A2, group IVA (cytosolic, calcium-dependent)

24653

2.04

0.0004

  1. *t-test.
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BMC Genomics

ISSN: 1471-2164

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