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Figure 1 | BMC Genomics

Figure 1

From: MicroRNAs and essential components of the microRNA processing machinery are not encoded in the genome of the ctenophore Mnemiopsis leidyi

Figure 1

Metazoan miRNA and siRNA pathways. Representation of standard metazoan models for canonical miRNA biogenesis, mirtron biogenesis, and siRNA processing. The Drosha/Pasha protein complex is specific to canonical miRNA biogenesis and initiates cleavage of the primary miRNA (pri-miRNA) from transcribed mRNAs. Intronic miRNAs (mirtrons) bypass cleavage by Drosha/Pasha, generating precursor miRNAs (pre-miRNAs) via intron splicing of mRNAs. The Dicer and Argonaute proteins are responsible for further processing and transport of miRNAs, in addition to short-interfering RNAs (siRNAs) from exogenous sources, resulting in repression of mRNA targets.

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BMC Genomics

ISSN: 1471-2164

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