A comprehensive survey of copy number variation in 18 diverse pig populations and identification of candidate copy number variable genes associated with complex traits

Table 2 Identification of potential candidate CNV genes for complex traits in the White Duroc × Erhualian F ₂ population

CNVR ID	CNVR region	Trait of overlapped QTL*	CNV gene	Phenotype in knockout mice	Reference
CNVR41	chr1: 267,977,629-268,124,492	carcass length	ANP32B	decreased body size	[39, 46]
CNVR62	chr2: 8,244,738-8,884,302	Backfat thickness	BSCL2	decreased subcutaneous adipose tissue	[40, 47]
		abdominal fat weight	BSCL2	decreased retroperitoneal fat pad weight	[40, 47]
CNVR61	chr2: 5,766,853-6,201,646	length of scapular	LTBP3	decreased length of long bones	[44, 48]
CNVR169	chr5: 65,533,763-65,810,346	intermuscle fat content of LD	GDF3	decreased white adipose tissue amount	[39, 49]
		body weight at 240 days	GDF3	abnormal developmental patterning	[40, 50]
CNVR199	chr6: 49,802,217-50,638,891	Glycolytic potential of LD	GYS1	decreased skeletal muscle glycogen level	[39, 51]
CNVR268	chr8: 43,425,758-43,955,459	mean corpuscular volume	KIT	increased mean corpuscular volume	[43, 52]
		mean corpuscular hemoglobin	KIT	decreased hemoglobin content	[43, 53]
				diluted coat color	[54]
CNVR560	chr18: 27,001,689-32,149,496	Humerus diameter	CAV1	increased bone size and stiffnes	[44, 55]

ISSN: 1471-2164