Figure 1

A natively unstructured domain accumulating non-synonymous changes. Section of a multiple sequence alignment (starting at position 550 in the alignment) showing the C-terminal, natively unstructured, region of the TcCLB.506553.20 gene, and its allelic counterparts in other strains. Asteriks indicate non-synonymous changes. The nucleotide multiple sequence alignment was obtained with TranslatorX, using the aminoacid translation as a guide[71]. The complete multiple sequence alignment is available as a Additional file6.