Altered gene expression profiles in the hippocampus and prefrontal cortex of type 2 diabetic rats

BMC Genomics

Table 3 List of significant pathways in the prefrontal cortex of type 2 diabetic rats.

GO Biological processes	PREFRONTAL CORTEX	Validated	Not validated
neurotransmission	GO:7611: learning and/or memory	Galr2, Prkcc, Gm2a
	GO:7268: synaptic transmission	Galr2, Prkcc, Grm2
	GO:1507: acetylcholine catabolism in synaptic cleft	Colq
	GO:1504: neurotransmitter uptake	Slc17a6
	GO:17158: regulation of calcium ion-dependent exocytosis	Trpv6
lipid metabolism	GO:1573: ganglioside metabolism	Gm2a
	GO:45332: phospholipid translocation	Abca1
others	GO:9649: entrainment of circadian clock	Bhlhb2
	GO:8228: opsonization	Cd47
	GO:6032: chitin catabolism	Chi3l1
	GO:6547: histidine metabolism	Ftcd
	GO:7497: posterior midgut development	Ret
	GO:30277: maintenance of gastrointestinal epithelium	Tff1
	GO:6936: muscle contraction	Galr2, Lsp1	Sgca_predicted
	GO:19882: antigen presentation	NM_001008842, RT1-Aw2 (Y13890)
	GO:9615: response to virus	Oas1	XM_215121
	GO:7635: chemosensory behavior	Prkcc, Prkce	Prkce

Data were obtained using the GO pathway analysis software; specific GO pathway identification numbers are provided in the second column. "Validated genes" were confirmed by quantitative PCR analysis. Validated genes found in more than 2 significant pathways are shown in bold.

ISSN: 1471-2164