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Table 3 Effect of a chronic Western diet on the expression of genes related to cholesterol metabolism in the livera

From: C57Bl/6 N mice on a western diet display reduced intestinal and hepatic cholesterol levels despite a plasma hypercholesterolemia

Symbol

Gene name

FC

p-value

Cyp51

Cytochrome P450, family 51

1.80 ± 0.28

0.056

Dhcr7

7-dehydrocholesterol reductase

1.72 ± 0.23

0.025

Hmgcr

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

2.23 ± 0.48

0.033

Pmvk

Phosphomevalonate kinase

1.22 ± 0.16

0.378

Srebp-2

Sterol regulatory element binding factor 2

1.37 ± 0.08

0.009

  1. a Abbreviations: FC fold change (Western diet vs. control)