Figure 1

Gene and domain mutational landscapes for colon and breast cancer Topographical maps depicting the frequency of somatic mutations in individual genes (1A and 1C) and domains (1B and 1D) from studies of 100 colon adenocarcioma and 522 breast invasive carcinoma patients. Each gene or domain is represented by a single point, and the heights of the peaks on the maps are proportional to the length normalized frequencies of somatic mutations occurring in each gene or domain. The “*” next to the arrow for the P53 domain peak in breast cancer (1D) denotes that the height of this peak was reduced to better show the landscape for the other domains.